Pills Insulin - Insulin injections are done every day feels painful for many diabetics. But now researchers are developing insulin in pill form. The pill test on animals shows promosing results.Pills Insulin, Insulin Injections Substitute.
Nearly 350 million people live with diabetes around the world, even in 2030, the number will increase to 500 million people. Although not all of them require insulin therapy, but nearly a quarter of diabetics rely on insulin injections. So the insulin pill sales are expected to reach 8 -17 million dollars.
Benefits of insulin pills not only replace the patient's dependence on insulin injections, but also allows patients to start insulin therapy early before the disease progresses to more severe. That is, insulin pills can reduce the risk of secondary complications of diabetes, such as blinddness and amputation of limbs.
Insulin pill idea has actually been around since the 1930, but the complexity of the manufacturing process causes the pill is hard to be realized. Because insulin is protein that when exposed to contact with stomach enzymes will break down immediately. Furthermore, if insulin would pass through the stomach without being damaged, meaning that the molecule must be made large, 30 times greater than with aspirin.
Though the size of large molecules that will not likely be absorbed by the bloodstream. If that does not happened then the effect of insulin pill will not distributed evenly throughout the body.
Even so, the research team Sanyog Jain in India's National Institute of Pharmaceutical Education and Research finally managed to find a pill of insulin form the result of many years of research. In 2012, they actually have developed a formulation that can control blood sugar in mice, but the material used is too expensive if it will be used as a commercial drug.
Now, researchers who published their study in the journal Biomacromolecules, managed to find a method that is less expensive and reliable to deliver insulin. That is by wrapping insulin with lipid (fat), and the addition of folic acid (vitamin B9) to improve the ability of insulin to be absorbed into the bloodstream.
In mice, these formulations work as effective as insulin injections. Although, the amount that can enter the bloodstream may still be different. Importantly, the effect can be last longer than insulin injections. Next, the researchers plan to conduct clinical trials of insulin pills in order to obtain marketing authorization of the drug.
Health and Safety - Source : health.kompas.com
Nearly 350 million people live with diabetes around the world, even in 2030, the number will increase to 500 million people. Although not all of them require insulin therapy, but nearly a quarter of diabetics rely on insulin injections. So the insulin pill sales are expected to reach 8 -17 million dollars.
Benefits of insulin pills not only replace the patient's dependence on insulin injections, but also allows patients to start insulin therapy early before the disease progresses to more severe. That is, insulin pills can reduce the risk of secondary complications of diabetes, such as blinddness and amputation of limbs.
Insulin pill idea has actually been around since the 1930, but the complexity of the manufacturing process causes the pill is hard to be realized. Because insulin is protein that when exposed to contact with stomach enzymes will break down immediately. Furthermore, if insulin would pass through the stomach without being damaged, meaning that the molecule must be made large, 30 times greater than with aspirin.
Though the size of large molecules that will not likely be absorbed by the bloodstream. If that does not happened then the effect of insulin pill will not distributed evenly throughout the body.
Even so, the research team Sanyog Jain in India's National Institute of Pharmaceutical Education and Research finally managed to find a pill of insulin form the result of many years of research. In 2012, they actually have developed a formulation that can control blood sugar in mice, but the material used is too expensive if it will be used as a commercial drug.
Now, researchers who published their study in the journal Biomacromolecules, managed to find a method that is less expensive and reliable to deliver insulin. That is by wrapping insulin with lipid (fat), and the addition of folic acid (vitamin B9) to improve the ability of insulin to be absorbed into the bloodstream.In mice, these formulations work as effective as insulin injections. Although, the amount that can enter the bloodstream may still be different. Importantly, the effect can be last longer than insulin injections. Next, the researchers plan to conduct clinical trials of insulin pills in order to obtain marketing authorization of the drug.
Health and Safety - Source : health.kompas.com
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